Publications

Recent:

Comparative analysis of cell therapy infusion workflows at clinical sites - Joules A, Connors J, Johnson R, Van Orsow E, McKenna D, Nikiforow S, Ritz J, Gee A, Hubel A, Cytotherapy, 2021

Natural deep eutectic systems for nature‐inspired cryopreservation of cells - Hornberger K, Li R, Duarte Ana Rita C, Hubel A, AIChE J. 2020; e17085:  DOI:  10.1002/aic.17085

A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity - Thibodeaux, S. R., McKenna, D. H., Szczepiorkowski, Z. M., Fontaine, M. J., Kelley, L., Reems, J. A. & Young, P. P., Aug 1 2020, In : Transfusion. 60, 8, p. 1811-1820 10 p.

Differential evolution for the optimization of the DMSO-free cryoprotectants:  influences of control parameters - Pi CH, Dosa PI, Hubel A, J Biomech Engr, 142 (7):  DOI: 10.1115/1.4045815.

Cryopreservation of human iPS cell aggregates in a DMSO-free solution-an optimization and comparative study -  Li R, Hornberger K, Dutton JR, Hubel A, Frontiers in Biotechnology, DOI: 10.3389/fbioe.2020.00001.

Interfacial interactions of sucrose during cryopreservation detected by Raman spectroscopy -  Yu G, Li R, Hubel A, Langmuir, 35(23): p. 7388-7395, 2019.m  DOI: 10.1021/acs.langmuir.8b01616

Characterizing modes of action and interaction for multicomponent osmolyte solutions on Jurkat cells - Pi CH, Yu G, Dosa PI, Hubel A. Biotechnol Bioeng. 2019 Mar;116(3):631-643. doi: 10.1002/bit.26880. Epub 2019 Jan 16.

 

 


Hubel Publications 

Select Publications

  • Natural deep eutectic systems for nature‐inspired cryopreservation of cells - Hornberger K, Li R, Duarte Ana Rita C, Hubel A, AIChE J. 2020; e17085:  DOI:  10.1002/aic.17085

  • Differential evolution for the optimization of the DMSO-free cryoprotectants:  influences of control parameters - Pi CH, Dosa PI, Hubel A, J Biomech Engr, 142 (7):  DOI: 10.1115/1.4045815.

  • Cryopreservation of human iPS cell aggregates in a DMSO-free solution-an optimization and comparative study -  Li R, Hornberger K, Dutton JR, Hubel A, Frontiers in Biotechnology, DOI: 10.3389/fbioe.2020.00001.

  • Understanding the freezing responses of T-cells and other subsets of human peripheral blood mononuclear cells using DSMO-free cryoprotectants - Pi CH, Hornberger K, Dosa PI, Hubel A, Cytotherapy, 22(5): 291-300, 2020. DOI: 10.1016/j.jcyt.2020.01.013.

  • Interfacial interactions of sucrose during cryopreservation detected by Raman spectroscopy -  Yu G, Li R, Hubel A, Langmuir, 35(23): p. 7388-7395, 2019.m  DOI: 10.1021/acs.langmuir.8b01616

  • Cryopreservation of hematopoietic stem cells:  emerging cryoprotectants, and technology to improve outcome - Hornberger K, Yu G, McKenna DH, Hubel A, Transfusion Med Hemotherapy, 4(3): p. 188-196, 2019. DOI: 10.1159/000496068

  • The role of preservation in the variability of regenerative medicine products -  Yu G, and Hubel A, Regen Engr and Trans Med, 5(4): 323-331, 2019,  doi.org/10.1007/s40883-019-00110-9

  • Preservation of cell-based immunotherapies for clinical trials - Li R, Johnson R, Yu G, McKenna DH, Hubel A, Cytotherapy, 21(9): 943-957, 2019.

  • Freezing responses in DMSO-based cryopreservation of human iPS cells:  aggregates versus single cells - Li R, Yu G, Azarin SM, Hubel A, Tissue Engineering:  Part C, 24 (5): 289-299, 2018. DOI: 10.1089/ten.tec.2017.0531

  • Characterizing the ‘Sweet spot” for the preservation of a T-cell line using osmolytes - Pi CH, Yu G, Petersen A, Hubel A, Scientific Reports, 8(1): p. 16223, 2018. DOI: 10.1038/s41598-018-34638-7.

  • Algorithm-driven optimization of cryopreservation protocols - Pollock K, Budenske JW, McKenna DH, Dosa PI, Hubel A, J Tissue Engr Regen Med, 10: 2806-2815, 2017. DOI: 10.1002/term.2175.

  • Characterizing intracellular ice formation of lymphoblasts cryopreserved in different cryoprotectant compositions using low temperature Raman microspectroscopy -  Yu G, Pollock K, Yap YR, Hubel A, Biophysical J, 112 (12): 2653-2663, 2017. DOI: 10.1089/ten.tec.2016.0284.

 

Skubitz Publications

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  • Storage of human biospecimens: selection of the optimal storage temperature - Hubel A, Spindler R, Skubitz AP.  Biopreserv Biobank. 2014 Jun;12(3):165-75. doi: 10.1089/bio.2013.0084. Epub 2014 Jun 11.

  • Isothermal vitrification methodology development for non-cryogenic storage of archival human sera - Less R, Boylan KL, Skubitz AP, Aksan A. Cryobiology. 2013 Apr;66(2):176-85. doi: 10.1016/j.cryobiol.2013.01.003. Epub 2013 Jan 24.

  • Development of the ISBER Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research - Campbell LD, Betsou F, Garcia DL, Giri JG, Pitt KE, Pugh RS, Sexton KC, Skubitz AP, Somiari SB.  Biopreserv Biobank. 2012 Apr;10(2):232-3. doi: 10.1089/bio.2012.1025.
  • Stabilization of tissue specimens for pathological examination and biomedical research - Unhale SA, Skubitz AP, Solomon R, Hubel A. Biopreserv Biobank. 2012 Dec;10(6):493-500. doi: 10.1089/bio.2012.0031.

  • Short-term stability study of RNA at room temperature - Mathay C, Yan W, Chuaqui R, Skubitz AP, Jeon JP, Fall N, Betsou F, Barnes M; ISBER Biospecimen Science Working Group. Biopreserv Biobank. 2012 Dec;10(6):532-42. doi: 10.1089/bio.2012.0030.

 

McKenna Publications

Select Publications:

  • A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity - Thibodeaux, S. R., McKenna, D. H., Szczepiorkowski, Z. M., Fontaine, M. J., Kelley, L., Reems, J. A. & Young, P. P., Aug 1 2020, In : Transfusion. 60, 8, p. 1811-1820 10 p.

  • Current practices for viability testing of cryopreserved cord blood products: an international survey by the cellular therapy team of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative - Minoko Takanashi, Eileen Selogie, Jo-Anna Reems, David Stroncek, Magali J Fontaine, John Girdlestone, Henk S P Garritsen, Pampee Young, David H McKenna, Zbigniew M Szczepiorkowski, Sep 2018, In : Transfusion. 58, 9, p. 2184-2191 8 p.

  • Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations - D Nicole Worsham, Jo-Anna Reems, Zbigniew M Szczepiorkowski, David H McKenna, Thomas Leemhuis, Aby J Mathew, Jose A Cancelas, Jun 2017, In : Transfusion. 57, 6, p. 1555-1565 11 p.

  • Impact of starting material (fresh versus cryopreserved marrow) on mesenchymal stem cell culture - Kaplan, A., Sackett, K., Sumstad, D., Kadidlo, D. & McKenna, D. H., Sep 2017, In : Transfusion. 57, 9, p. 2216-2219 4 p.

 

Dosa Publications

Select Publications:

  • Differential Evolution for the Optimization of DMSO-free Cryoprotectants: Influence of Control Parameters - Pi CH, Dosa PI, Hubel A. J Biomech Eng. 2019 Dec 1. doi: 10.1115/1.4045815.
  • Characterizing modes of action and interaction for multicomponent osmolyte solutions on Jurkat cells - Pi CH, Yu G, Dosa PI, Hubel A. Biotechnol Bioeng. 2019 Mar;116(3):631-643. doi: 10.1002/bit.26880. Epub 2019 Jan 16.

  • Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions - Pollock K, Samsonraj RM, Dudakovic A, Thaler R, Stumbras A, McKenna DH, Dosa PI, van Wijnen AJ, Hubel A.Stem Cells Dev. 2017 Jun 1;26(11):828-842. doi: 10.1089/scd.2016.0347. Epub 2017 Mar 15.
  • Combinations of Osmolytes, Including Monosaccharides, Disaccharides, and Sugar Alcohols Act in Concert During Cryopreservation to Improve Mesenchymal Stromal Cell Survival - Pollock K, Yu G, Moller-Trane R, Koran M, Dosa PI, McKenna DH, Hubel A. Tissue Eng Part C Methods. 2016 Nov;22(11):999-1008. doi: 10.1089/ten.TEC.2016.0284. Epub 2016 Oct 27.

 

Wendt Publications

Select Publications:

  • State of the art in preservation of fluid biospecimens - Allison Hubel, Alptekin Aksan, Amy P N Skubitz, Chris Wendt, Xiao Zhong.  Biopreserv Biobank. 2011 Sep;9(3): 237-44. doi: 10.1089/bio.2010.0034

  • Isolation of fibroblasts and epithelial cells in bronchoalveolar lavage (BAL) - Kathryn Pollock, Luke Albares, Chris Wendt, Allison Hubel.  Exp Lung Res. 2013 Apr;39(3):146-54. doi: 10.3109/01902148.2013.781720

 

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